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Incomplete or missing 1572
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Missing Curriculum Vitae
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Incomplete Research Site Submission Form
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Principal Investigator conflict of interest
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Enrollment via Legally Authorized Representative when prohibited by protocol
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Enrollment from vulnerable groups when prohibited by protocol
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Follow-up on FDA audit findings
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Disciplinary actions against investigators (e.g. state medical board)
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Compensation issues
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Informed consent document (ICD) being revised due to risk
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ICD awaiting sponsor/CRO sign-off
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Protocol on hold
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Sponsor has not satisfied the conditions of approval
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Site specific language added to the ICD
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